Topic: necroptosis

VPS10P domain receptors are intracellular sorting receptors which direct their protein cargo to destined subcellular localizations. Although it seemed that functions of VPS10P receptors in the brain are restricted to neurons, it turned out they are also relevant for glial cells, including microglia, which dependently on pathological context may acquire different functional properties. For instance, during glioblastoma progression, microglia along with infiltrating macrophages are reprogrammed, so instead of fighting with glioma they support it, mainly through secretion of pro-tumorigenic facto

Synthetic cannabinoids as potent recreational drugs disrupt the endocannabinoid system in the brain, leading to severe mental and behavioral consequences. Cumyl-PINACA or SGT-24 is a synthetic agonist designed to bind cannabinoid receptor 1 (CB1) with very high affinity, yet the molecular mechanisms underlying its central toxic effects are poorly understood.In this study, we investigated the response of rat cortical neurons and astrocytes to SGT-24 at nanomolar concentrations (0.1 - 1000 nM). The effects of SGT-24 were dose- and time-dependent, as well as cell-specific. In neurons, 10 nM SGT-2