Topic: neonatal hypoxia-ischemia

Neonatal hypoxia-ischemia (HI), restricted oxygenation and reduced cerebral bloodflow to the brain is a significant cause of neonatal morbidity and mortality. Therapeutic Hypothermia (TH) is the only licensed treatment for HI, however, 40% of TH-treated neonates still develop neurodevelopmental disabilities. Curcumin induces powerful antioxidant activity, with evidence of significant neuroprotection in a neonatal HI mouse model. However, curcumin has limited therapeutic usage due to poor bioavailability and aqueous insolubility. This study aimed to: i) compare free synthetic vs natural curcumi

Neonatal hypoxia-ischemia is a severe condition that can result in death and/or lifelong central nervous system sequelae. Benefits of cannabidiol (CBD) result from neuroprotection asssumed to be mainly due to targeting a variety of neuronal receptors. The results of this article first show that CBD protects both primary neurons and primary glia against death induced by glucose and oxygen deprivation. Second, the expression of glial markers in an animal model of neonatal hypoxia-ischemia treated with vehicle or CBD shows that the cannabinoid was able to skew microglia towards a neuroprotective

Introduction: Neonatal hypoxia-ischemia (HI) is a leading cause of mortality and chronic disability. Hypothermia (HT) is the gold standard for the treatment of term babies; however, its neuroprotective effects are limited. Lactoferrin (LF) is the major whey protein in milk presenting iron-binding, anti-inflammatory and anti-apoptotic against HI damage. We hypothesize that combining oral administration of LF to the dams enhances the neuroprotection caused by HT following experimental HI. Methods: Pregnant Wistar rats were fed with bovine LF-supplemented diet (1mg/kg) or Control diet from P6 to