ePoster · Computational Neuroscience
A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations
Christoph Pokorny, Omar Awile, James Isbister, Kerem Kurban, Matthias Wolf, Michael Reimann · Bernstein Conference 2024
Even with complete knowledge of the underlying wiring diagram using electron microscopy and the neuronal activity through $in~vivo$ recordings, we can only ever correlate neuron function with participation in the various non-random motifs that have been characterized [1, 2]. Causation, however, can only be proven by manipulations of connectivity, which can experimentally only be pursued on coarse-grained scales or low specificity. Higher resolution and specificity can to date only be reached using simulation techniques. Here, we present a novel framework [3] for rapid connectome manipulations