Recent advances in organoid production and drug discovery
This English-language webinar examines advances in organoid research, production, and drug discovery. Hideya Sakaguchi covers the developmental-biology origins of neural organoid research and its potential for drug discovery, followed by a keynote from Thomas Mitchell of The Organoid Company and a live question session.
Computational models of neural development
Unlike even the most sophisticated current forms of artificial intelligence, developing biological organisms must build their neural hardware from scratch. Furthermore they must start to evade predators and find food before this construction process is complete. I will discuss an interdisciplinary program of mathematical and experimental work which addresses some of the computational principles underlying neural development. This includes (i) how growing axons navigate to their targets by detecting and responding to molecular cues in their environment, (ii) the formation of maps in the visual cortex and how these are influenced by visual experience, and (iii) how patterns of neural activity in the zebrafish brain develop to facilitate precisely targeted hunting behaviour. Together this work contributes to our understanding of both normal neural development and the etiology of neurodevelopmental disorders.