Neural substrates

…that if I could identify taste neural substrates along this pathway, it would provide an entry to decipher how taste signals are

The primary motor cortex (M1) is a major output center for movement execution and motor learning, and its dysfunction contributes to the pathophysiology of Parkinson’s disease (PD). While human studies have indicated that a loss of midbrain dopamine neurons alters M1 activation, the mechanisms underlying this phenomenon remain unclear. Using a mouse model of PD, we uncovered several shifts within M1 circuitry following dopamine depletion, including impaired excitation by thalamocortical afferents and altered excitability. Our findings add to the growing body of literature highlighting M1 as a

…knowledge, and what are the neural substrates for the acquisition of conscious and unconscious knowledge. In this talk, I will discuss with you about these ongoing questions.