Topic: neuronal computations

Brains of different individuals perform common essential functions despite differences in character, skills, perception or learning abilities. These fundamental observations suggest that neuronal computations exhibit different degrees of invariance to natural variability in the structure and dynamics of neuronal circuits. To understand the relation between structural and functional variability in a complex sensory network we focus on the olfactory bulb (OB) of larval zebrafish. The OB is optically accessible and sufficiently small to enable dense ultrastructural reconstructions of neuronal cir

Understanding how sensory information is represented, processed, and leads to generation of complex behavior is the major goal of systems neuroscience. However, the ability to detect and manipulate such large-scale functional circuits has been hampered by the lack of appropriate tools and methods that allow for parallel recording of neuronal population activity at high spatial and temporal resolutions. We have recently demonstrated near-simultaneous recording from over 1 million neurons distributed across both hemispheres and different layers of the mouse cortex at cellular resolution. At the