Topic: neuronal-glial co-cultures

SARS-CoV-2 virus can produce pathogenic molecules such as ssRNA, dsRNA, spike protein can be recognized by microglial cells. However, it’s not known whether exposure to these pathogens can result in microglia-mediated neuronal damage. We aimed to investigate whether SARS-CoV-2 S1 protein and repeated treatment with mRNA vaccines can induce microglial activation and neuronal death in mixed neuronal-glial co-cultures. We treated primary rat neuronal-glial co-cultures for 3 and 7 days with SARS-CoV-2 S1 recombinant protein or mRNA Original/Omicron B.A 4-5 and Tozinameran/Riltozinameran vaccines,

A growing body of evidence suggests a potential link between neuroinflammation, directly or indirectly triggered by viral infections, and the initiation or progression of neurodegenerative diseases such as Parkinson's disease (PD). Viral infections can potentially induce pathological alterations in amyloidogenic proteins such as a-synuclein (αSyn) implicated in pathogenesis of this disease. However, the exact molecular mechanisms of virus-induced neuroinflammation remain unclear.To get insights into mechanisms of viral RNA-induced neurotoxicity, we treated rat neuronal-glial co-cultures (CGC)