Topic: neuronal homeostasis

Numerous long non-coding RNAs (lncRNAs) play pivotal roles in nervous system development and the modulation of neuronal activity, making them crucial physiological players and potential vulnerability points for neuropsychiatric disorders. MALAT1 stands out as one such lncRNA, exerting control over splicing events by sequestering specific SR-family splicing factors in nuclear inactive compartments such as the nuclear speckles, thereby impeding their action on target transcripts. Notably, nSR100, a member of the SR-family, serves as a key splicing regulator, facilitating the generation of neuroL

The brain, particularly the hippocampus, is sensitive to age-related cellular changes, leading to cognitive deficits. Recent work by our laboratory has demonstrated that autophagy, a catabolic lysosomal-dependant process, is reduced in aged hippocampal neurons, and that restoring autophagy levels is sufficient to improve age-related memory impairment. Nonetheless, the regulatory mechanisms involved in neuronal autophagy decline during aging remain largely unknown. Exploring this question, we found that WD repeat domain phosphoinositide-interacting protein 2 (WIPI2), an important driver of auto