Topic: neuronal morphology

Neuroplasticity is essential for the establishment and strengthening of neural circuits. Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate cortical excitability and shows promise in the treatment of some neurological disorders. Low intensity magnetic stimulation (LI-rTMS), which does not directly elicit action potentials in the stimulated neurons, have also shown some therapeutic effects, and it is important to determine the biological mechanisms underlying the effects of these low intensity magnetic fields, such as would occur in the regions surrounding the cent

To understand the function of the brain and how its dysfunction leads to brain diseases, it is essential to have a deep understanding of the cell type composition of the brain, how the cell types are connected with each other and what their roles are in circuit function. At the Allen Institute, we have built multiple platforms, including single-cell transcriptomics, single and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, high throughput brain-wide connectivity mapping, and large-scale neuronal activity imaging, to characterize the transcriptomic, physiological, m

Neuronal morphology plays a fundamental role in determining the neuronal network's function. However, understanding the effect of single neuron morphology on whole-brain function is still an open challenge. Limited by resolution and time cost, current studies on the functional properties of whole-brain connectivity are mainly described with simulations from the mesoscale perspective, like those generated in The Virtual Mouse Brain (TVMB) platform. Whole mouse brain activity is simulated using connectivity weights between brain regions obtained from tracer injections in populations of neurons a