Topic: neuronal network activity

Glucocorticoid signalling serves as a central regulator of the body's stress response and has been associated with several diseases affecting the central nervous system (CNS), such as major depressive disorder or Alzheimer’s disease. While the cell type-specific effect of glucocorticoids in the CNS has been studied previously, our understanding of how glucocorticoids act on astrocytes and their impact on neuronal network plasticity is limited. It's important to note that only 1.5% of the genome encodes proteins, while the remaining 98.5% consists of non-coding RNAs (ncRNAs) implicated in vario

Non-coding RNAs are transcripts that do not encode proteins and comprise 98.5% of the human transcriptome. Among these, long non-coding RNAs (lncRNAs) have been implicated in various biological functions, including the control of gene expression and translation. The central nervous system (CNS) harbors a diverse array of lncRNA transcripts, yet the functions of many remain largely unexplored. In this study, we employed bulk and single-cell RNA sequencing approaches using human and mouse brain tissue to identify novel lncRNAs in both neuronal and non-neuronal cells, potentially associated with