Topic: neuronal nitric oxide synthase

Cortical activity changes dramatically upon changes in behavioral state, such as between sleep versus wake (McGinley et al 2015). Though the mechanisms enabling these distinct modes of cortical operation remain largely unknown, inhibitory neurons (INs) have been suggested repeatedly as a regulator of behavioral-state dependent neocortical activity (Batista-Brito et al 2018, Cardin et al 2019, Bugeon et al 2021). Here we investigate how a unique subpopulation of long-range INs impact cortical states. These cells are defined by the co-expression of somatostatin (SST) and neuronal nitric oxide sy

Arousal states, such as sleep and wake, are highly correlated with specific rhythmic activity patterns in the neocortex. For example, during sleep, neocortical rhythms are synchronized and dominated by low-frequency oscillations. Recent evidence suggests that inhibitory neurons (INs) are key regulators of neocortical states.Here we investigate how neocortical long-range INs that co-express somatostatin (SST) and neuronal nitric oxide synthase (nNOS) (“SST/nNOS cells”), control patterns of synchronous neocortical activity and arousal states in mice. While the in-vivo function of SST/nNOS cells

Multiple sclerosis (MS) is a devastating demyelinating disease of the central nervous system (CNS), characterised by white matter lesions, inflammation, and axonal degeneration.Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are endogenous neuropeptides whose signalling is mediated by three G-protein coupled receptors: PAC1, VPAC1 and VPAC2. While these neuropeptides are known for their neuroprotective and anti-inflammatory activities in the CNS, their role in preventing demyelination, neuronal degeneration and neuroinflammation is unclear. Th