Topic: neuronal NOS

A lot of complications associated with type 2 diabetes mellitus (T2DM) are closely linked with the generation of reactive species or free radicals leading to oxidative/nitrosative stress. The aim of this study was to investigate the effect of combined administration of metformin with propionate on the degree of oxidative/nitrosative damage in the brain of rats with an experimental model of T2DM. Male Wistar rats were divided into control (healthy rats); rats with T2DM and no further therapy; rats with T2DM that received the following: metformin or propionate or propionate + metformin. Ventrome

Dynamic alterations in mitochondrial Ca2+ levels are recognized for their role in regulating both mitochondrial and cellular functions, as well as influencing energy metabolism (1). Recent studies reported that mitochondrial Na+/Ca2+ exchanger (NCLX) is regulated by PKA phosphorylation on its regulatory domain and PDE2 plays a crucial role as a physiological determinant in the PKA-mediated regulation of NCLX (2, 3). A major unsolved question is what links the cell membrane signaling to mitochondria NCLX regulation. Here, we fluorescently monitored [Ca2+]m efflux mediated by the NCLX in mice hi