Topic: neuronal progenitor cells

Neurodevelopment is a highly orchestrated and precisely timed process that displays vulnerability towards environmental insults. Maternal immune activation (MIA) during gestation can disturb this delicate balance and increase the offsprings risk for neurodevelopmental disorders like schizophrenia and autism later in life.This study investigates the differential impact of MIA on neuronal progenitor cells at E10.5 (polyI:C administration at E9.5) by using single-cell RNA sequencing. Additionally, we examined the role of microglia in mediating the effects of MIA at different developmental stages.

Vaccinia-related kinase 1 (VRK1) is a predominantly nuclear serine/threonine kinase implicated in nucleus disassembly and reassembly, cell cycle, and transcription regulation. VRK1 mutations in humans have been linked to several neurodegenerative diseases, including spinal muscular atrophy associated with microcephaly and impaired cognitive and motor function. Thus, it has been identified as potentially involved in the maintenance and development of the nervous system. However, precise pathophysiological mechanisms and VRK1 involvement in cognitive and motor dysfunction progression have yet to