Neurotoxicity

…seizure risk, abuse potential, and neurotoxicity, alongside emerging regulatory perspectives on New Approach Methodologies. The talk explains how combining these data can improve candidate selection and confidence in the safety of both CNS-targeted and other therap

…leakage of the blood-brain barrier and neurotoxicity. Transient neuroinflammation is understood to be largely protective, chronic neuroinflammation, however, contributes to the pathology of Alzheimer’s disease, traumatic brain injury, and many more. In this study, we focus on the aspect of cytokine-induced neuroinflammation in human microglia cells and especially in astrocytes, since many studies on

…key players in this pathology, causing neurotoxicity and neuronal death after excessive stimulation. On the other hand, the cannabinoid receptor CB1 induces a neuroprotective role. In this research we aim to analyze the capacity of the CB1R to regulate and reduce NMDAR overstimulation in Alzheimer's pathology.Results: It has been demonstrated that CB1R and NMDAR colocalize and form heteromeric complexes in transfected HEK-293T cells. In the same cells, NMDAR activ

…very little is known about Gly neurotoxicity at this dosage, especially on intricate mechanism such as the communication between brain cells. Astrocytes contribute to neuron maturation, survival, and modulation of synaptic activity also throu

…tablets, but have been found to cause neurotoxicity. However, it remains elusive whether PFCs affect neural survival or activity, or whether they alter different neuronal regulations in the brain. Additionally, there is a paucity of data on the regulatory mechanisms involved in PFCs-induced neural toxicity.In the current study, we report that PFOA or PFHpA differentially alter neural survival and activity in pri

Lindane is organochloride environmentally persistent pollutant used manly as pesticide. Neurotoxicity of lindane is manifested through cellular and behavioral changes including expression of anxiety, seizures and lethal outcome in higher doses. Ferulic acid is polyphenol organic compound with antioxidant and anti-inflammatory effects in different tissues including neuroprotective effects in acute and chronic application. We hypothesized that it could ameliorate some of the lindane neurotoxic effects. Therefore, we investigated the effects of ferulic acid chronic supplementation on anxiety-like

…been associated to neurodegeneration, neurotoxicity, and proinflammatory responses, even at low concentrations and is thought to be involved in Parkinson’s disease (PD) pathogenesis.To date, it is not clear whether the neurotoxicity exerted by α-syn aggregates is due to the presence of scattered oligomeric species, anticipating the formation of proper fibrillary α-syn, or whether it is sustained by α-syn species that are already

Endocrine disruptors (EDs) are ubiquitous compounds with the ability to interfere with endogenous hormones. Molecules identified as EDs are highly heterogeneous, but most of them are man-made chemicals, such as ethinyl estradiol (EE), medication, perfluorooctanesulfonic-acid (PFOS), surfactant, and diethyl-phthalate (DP), plasticizer. The constant exposure of the global population to these molecules can lead to an induction of toxic effects, especially on the central nervous system. Among the different mechanisms by which EDs could influence human health, of interest is the modulation of micro

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motoneurons (MNs). Our previous results revealed that intravenous administration of mesenchymal stem cells (MSCs) improved different pathological features in SOD1G93A ALS mice. We hypothesised that the beneficial effect could be mediated by paracrine activity of extracellular vesicles (EVs) secreted by MSCs shuttling microRNAs . Subsequently, we studied in-vitro the activity of MSCs-derived EVs on spinal cord astrocytes of symptomatic SOD1G93A mice. The results demonstrated that 24h in-

…is known about the infectivity, the neurotoxicity, and the neuroinvasiveness of prions. Also, I will explain why I regar

Parkinson's disease (PD) is the second most present neurodegenerative disease in the world after Alzheimer's. It is due to the progressive and irreversible loss of dopaminergic neurons of the substantia nigra Pars Compacta. Alpha synuclein deposits and the appearance of Lewi bodies are systematically associated with it. PD is characterized by four cardinal motor symptoms: bradykinesia / akinesia, rigidity, postural instability and tremors at rest. These symptoms appear when 80% of the dopaminergic endings disappear in the striatum. According to Braak's theory, non-motor symptoms appear much ea