Topic: NF-kB

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder associated with memory and cognitive deficits. Both amyloid β (Aβ) deposition and inflammatory response occur in the early course of AD, but the progression of cognitive impairment and its relationship with Aβ and neuroinflammation have not been fully understood. Dieckol is a phenolic compound from brown algae and has been reported to possess several health benefits. In particular, our previous studies have shown that the compound exerts the neuroprotective effects by inhibiting amyloidogenesis, oxidative stress and inflamma

Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by movement disorders. The main characteristic of PD is the loss or degeneration of dopaminergic neurons in the substantia nigra. The gut microbiota is now recognized as a potential participant in the pathogenesis of PD. This study aims to investigate the effects of Lactobacillus sakei (Ls) on the gut-brain axis and explore the underlying molecular mechanism using a PD model. Probiotics were orally administered for four weeks after MPTP injection. The study observed that Ls significantly improved movement, includi

Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Among other factors, microglia are thought to take part in the chronic neuroinflammatory scenario that contributes to the process of neuronal death. However, the factors that maintain the overreactive response of microglia in PD remain mysterious. As we wanted to simulate the chronic neuroinflammatory scenario taking place in PD, we evaluated the response of microglial cells after repetitive pro-inflammatory stimuli induced by LPS and IFN-g in vitro. In contrast w