Topic: object recognition memory

Ventral pathway circuits are constituted by the interconnected brain areas that are distributed throughout the brain. They are primarily involved in processing of object related information in brain. However, their role in object recognition memory (ORM) enhancement remains unknown. In this study, we show that an activation of each of the brain areas interconnected to ventral pathway circuits individually induced enhancement in ORM; however, same treatment in brain areas not interconnected to ventral pathway circuits produced no effect. Further study in perirhinal cortex (PRh), area V2 of visu

Neuroimmune dysregulations strongly contribute to the pathophysiology of Alzheimer's Disease (AD). Because pathogens shape the immune system over lifetime, their association with AD has been suggested. Increasing evidence supports a role for the prevalent, brain-persisting parasite Toxoplasma gondii (Tg) in chronic neurological diseases. Yet, the contribution of Tg chronic infection on AD clinical progression and pathogenesis remains unexplored. Considering the temporal relationship between natural Tg infection and AD occurrence, it seems legitimate to evaluate the effects of a seemingly silen

Cognitive impairments associated with schizophrenia (CIAS) are modelled in rodents using sub-chronic administration of phencyclidine (scPCP). Changes to inflammatory markers have been associated with CIAS in patients, while exercise can improve cognition clinically and pre-clinically. This study aimed to investigate the effect of exercise on cognition and inflammation in the scPCP mouse.Adult female c57 mice were dosed with vehicle (0.9% saline, n=28) or PCP (10mg/kg, n=28) once daily for 10 days and divided into sedentary or exercised groups. Exercised mice had running-wheel access for 1h dai

Aims: Post-injury physical exercise can reduce memory deficits associated to traumatic brain injury (TBI) in late adolescent and young adult rats, but both the effectiveness of this treatment and possible sex-dependent effects in late middle-aged injured rats are important issues still unsolved. The aim of the present work was to examine whether chronic object recognition memory (ORM) deficits associated to TBI can be alleviated by post-injury physical exercise in males and females late middle-aged rats. Methods: 14 months-old rats were submitted to a controlled cortical impact injury model of