p62

…of proteins including Ubiquitin and p62, which are usually involved in cellular degradation pathways. The abundance of CAs is strikingly increased in neurodegenerative conditions such as Alzheimer’s disease (AD), suggesting that the occurrence of CAs might either be a protective mechanism or a co-morbidity in the aging human brain. To understand the fo

Wasteosomes (or corpora amylacea) appear in the human brain during aging and in some neurodegenerative conditions. They entrap waste substances originated from different cell types and can be released from the brain to the cerebrospinal fluid (CSF). Their presence in the CSF was described using electron microscopy, PAS staining and immunofluorescence with natural IgMs and anti-glycogen synthase (GS) antibodies. However, the methods employed involved the use of a large sample volume for each staining, which hindered wasteosomes characterization. In the present work, we examined a new method to

Introduction: Rett syndrome (RTT) is a rare neurodevelopmental disorder caused in 95% of cases by mutations in the X-linked methyl CpG-binding protein 2 (MeCP2) gene. Although apparently normal at birth, RTT patients manifest a regression phase between 6-18 months of age characterized by loss of speech, impaired motor functions, seizures and intellectual disabilities. Clinical and animal studies suggested that metabolic pathways might be affected and contribute to RTT pathophysiology. Autophagy is a catabolic process involved in the degradation of cellar debris and recently found to regulate a

Spinal cord injury (SCI) results from direct damage to the spinal cord, devastating patients’ quality of life and emotional and economic stability. Unfortunately, fully effective therapeutic strategies have yet to be developed to treat this disease, affecting millions worldwide. Apoptosis and autophagy are critical cell death signaling pathways after SCI that should be targeted for early therapeutic interventions to mitigate their adverse effects and promote functional recovery. Tibolone (TIB) is a selective tissue estrogen activity regulator (STEAR) with neuroprotective properties demonstrate