Topic: pain ratings

Pain is constructed in the brain by integrating multimodal information, ranging from noxious inputs to expectations. Previous studies have identified brain systems that mediate the effects of different components of pain, but the computational mechanisms of their integration have been understudied. Here we examined whether the neural trajectories of different component subspaces would reveal the computational principles of information integration. To this end, we conducted a cue-induced pain expectation experiment with functional Magnetic Resonance Imaging in humans (N = 56) to examine the com

The promise of fMRI to detect robust inter-individual differences in health and behavioural outcomes and its potential use as a biomarker has been increasingly called into question. In a recent study (Hoeppli et al., 2022), the authors argued that, in the context of pain perception, fMRI was sensitive to small differences in applied noxious stimuli within an individual, but failed at predicting inter-individual differences. Here, we test in six studies whether this absent predictive power can be restored by accounting for inter-individual variance and the use of clearly distinguishable experim