Topic: pain sensitivity

Chronic pelvic pain syndrome (CP/CPPS) is frequently accompanied by brain-related comorbidities including anxiety, but the mechanisms of this relationship are far from being elucidated. Having in mind that gaseous neurotransmitter CO signaling could be included in anxiogenesis, we hypothesized that some of the anxiety states in CPPS could be attributed to CO signaling. Therefore, this study aimed to investigate the effects of CORM-A1 (slow realizing CO donor) on anxiety-related behavior and pain sensitivity in rats with experimentally induced CP/CPPS. CP/CPPS was induced in male rats by 3% λ-c

Sex is an important factor in the progression and treatment of alcohol addiction, and therapeutic approaches may have to be tailored to potential sex differences. This highlights the importance of understanding sex differences in behaviors that reflect key elements of clinical alcohol addiction, such as compulsive use.Large populations of genetically heterogeneous male and female Wistar rats were tested in an established model of compulsive alcohol self-administration, operationalized as alcohol responding despite contingent foot shock punishment. We also tested baseline alcohol self-administr

Polycystic ovary syndrome (PCOS) stands out as the most prevalent reproductive disorder affecting women, impacting hormonal and metabolic equilibrium. It can manifest as hyperandrogenism, insulin resistance, anovulation, and infertility. PCOS is associated with various symptoms such as obesity, hirsutism, and acne, which, in turn, elevate the risk of conditions like endometrioma, type 2 diabetes, cardiovascular disease, and irritable bowel syndrome. Previous data from our research indicated that PCOS accelerates pain perception in patients, yet the underlying mechanism remains elusive.In this

Chronic pain is often secondary to medical conditions such as cancer or diabetes or surgery (ICD-11). One of the major puzzles in the field is why some people with seemingly identical conditions do not suffer from pain. Psychosocial predictors determine the pain severity. The aim of this study was to investigate factorial structure of predictor variables in a population without the confounder of coexisting chronic pain.This study is a follow-up of the studies conducted with the BioPain subproject of the IMI-PainCare project. Here we analyzed data collected in 6 different countries.During a scr

Pain is considered one of the most frequent non-motor symptoms of Parkinson’s disease (PD) and it usually manifests before the motor symptoms. Although not considered one of the cardinal symptoms of PD, pain affects up to 80% of PD patients and half of them report multiple types of pain. The cause of this pain is still unknown, but it may be due to dysfunction of key nuclei in the processing of nociceptive information.In order to determine the possible causes of this prodromal symptom, we use different parkinsonian models, such as the hα- syn1-120 model, which presents a differential expressio

The endocannabinoid system influences virtually all central nervous system processes: learning, memory, appetite, emotions, and more. Growing evidence suggest that modulation of the endocannabinoid system by endogenous or exogenous cannabinoids may be significant in the treatment of various diseases. Tetrahydrocannabinol (THC) is the main psychoactive substance found in cannabis has been used as a pain medication due to its sedative effect. However, a whole series of other phytocannabinoids have been isolated, such as cannabinol (CBN), cannabidiol (CBD), tetrahydrocannabivarin (THCV) and Δ9-Te