Topic: palmitic acid

Type 2 diabetes mellitus (T2DM) is associated with a nearly 2-fold increased risk of Alzheimer's disease (AD) development although the reasons for this are unknown. Recent studies have reported dysregulated hippocampal neurogenesis in AD patients during postmortem examinations. Additionally, impaired neurogenesis has been observed in T2DM mouse models, suggesting this could explain the connection between T2DM and AD. This study aims to investigate how exposure to fatty acids associated with T2DM affects neuronal differentiation, serving as a model of neurogenesis. Human SH-SY5Y neuroblastoma c

Alzheimer Disease (AD), the most common neurodegenerative disease in elderly has been recently associated with the consumption of high fat diets in which Palmitic Acid (PA) is one of the principal components. Recent studies have shown that neurons can metabolize PA through β-oxidation leading to an increase in ATP levels, decrease in NAD+ concentration and reduced Sirtuin 1 expression and activity. These processes converge on the regulation of different signaling pathways that could regulate and impact posttranslational modifications (PTMs) of tau protein. To elucidate the kinases involved in