Modulating the astrocyte reactivity by blocking P2X7R and Panx1 in vitro – intercepting the neuroinflammation chronicity development
Marija Adzic Bukvic, Ivana Stevanovic, Katarina Milicevic, Nadezda Nedeljkovic · FENS Forum 2024
Neural cells and tissue injury lead to abundant release of ATP from the cell. Additionally, ATP could be cut loose through the activated Pannexin 1 hemichannels. Extracellular ATP could activate P2X7R, P2 ligand-gated ion channels, activating the inflammasome in microglia and astrocytes. P2X7R and Panx1 could create forward feedback loop, that potentiates and drives the chronicity of previously initiated neuroinflammation. Both P2X7R and Panx1 are upregulated in multiple neurodegenerative diseases, hypoxia, injuries, depression, epilepsy, and pain. Targeting one or both P2X7R and Panx1 has bec
ePoster · Neuroscience