Periorbital mechanical allodynia

Migraine is a pain disorder that affects 10 – 15% of the population worldwide. Even though there is a wide choice of therapeutics that includes different classes of well-tolerated drugs, numerous patients are still not satisfied with their treatment. Trigeminal ganglion and nucleus caudalis are enriched with nociceptin/orphanin FQ (N/OFQ) receptor (NOP)-expressing cells. The general aim of the present study is to investigate the role of the N/OFQ – NOP system in the modulation of migraine. This study evaluated the phenotype of mice with genetically induced knockout of the NOP receptor gene (NO

Migraine is a recurrent headache disorder characterized by episodes of acute pain. The overall objective of this work, was to test the hypothesis that the NLRP3 inflammasome is involved in the pathophysiology of migraine and that NLRP3 blockade may represent a novel strategy for migraine management through the design of novel inhibitors. The phenotype of NLRP3 knockout (NLRP3 KO) mice has been investigated in a mouse model of migraine induced by the i.p. administration of nitroglycerin (NTG). Using the same model, were tested the effects of MCC950, a standard NLRP3 inhibitor able to cross the