Topic: allodynia

Migraine is a neurological disorder manifested by throbbing pain, allodynia, as well as light sensitivity (photophobia). Despite continuing research, the pathogenesis of the disease is not precisely understood. Structures implicated in migraine formation, including the trigeminal ganglia and trigeminal nucleus caudalis, exhibit a particularly high expression of Nociceptin Opioid (NOP) receptors. The aim of the study was to compare the effect of selective and non-selective NOP receptor agonists on acute migraine symptoms induced by systemic administration of nitroglicerin (NTG). NTG induces mig

Neuropathic pain is evoked by an injury to the somatosensory system at the peripheral or central nervous system level leading to direct changes in neuronal activity. Moreover, there is a large body of evidence that changes occurring in primary peripheral sensory neurons also alter secondary central circuits thus causing hyperalgesia and allodynia. The latter are hallmarks of neuropathic pain and recent work suggests that both of those sensory abnormalities depend on alterations in spinal dorsal horn circuits likely caused by a loss of local inhibition. However, the molecular mechanisms that le