Topic: peripheral nerve regeneration

Peripheral nerve injury is an important health problem that threatens public health. The aim of this study is to investigate the effects of a biocellulose (BC) conduit and a biocellulose conduit impregnated with vascular endothelial growth factor (VEGF) on peripheral nerve regeneration. Biocellulose derived from Gluconacetobacter xylinus cell culture was impregnated with 0.2 µm/ml VEGF and formed into conduits. Unilateral 8-millimeter rat sciatic nerve defects were repaired using biocellulose conduit, VEGF-impregnated biocellulose conduit, and an autograft. Walking analysis was conducted at sp

Aim: Methylcobalamin (MeCbl) is known to promote peripheral nerve regeneration and polarize macrophage to M2. In recent years, it has been reported that the regeneration of peripheral nerves and the polarization of macrophages to M2 are important for bone formation. The purpose of this research is to examine the effects of MeCbl on bone formation via peripheral nerves and macrophages. Methods: Effects of MeCbl were evaluated using rat skull defect models. Briefly, we created a bone hole in the rat skull, and evaluated the bone formation rate in the defect area in a group that received continuo

Aims. Interleukin-33 is a protein enhancing Th2 cytokine production, initially described as an alarmin that is released from dying, necrotic cells to affect the immune response. Therefore, we aimed to examine the role of IL-33 in response to both CNS and PNS injury. Methods and Results. Using qPCR, Western blotting, and ELISA assay we showed significant up-regulation of IL-33 in two models of nervous system pathology in response to demyelination of the CNS white matter and sciatic nerve crush. We showed that IL-33 is produced exclusively by non-myelinating oligodendrocytes in the intact white