Topic: photoinhibition

A common approach to analyzing spike train data in stimulus-response experiments is to estimate spike rates relative to the stimulus onset. These experiments typically involve collecting measurements from the same subject across several trials and sessions, and performing the same experiment across multiple subjects. Accounting for these sources of variability is important to accurately estimate the population response. However, current spike rate estimation methods only allow for estimating trial-level, session-level or group-level spike rates, neglecting the variability between levels. We de

Working memory (WM) is a cognitive function that allows for the short-term maintenance and manipulation of information when no longer accessible to the senses. It relies on temporarily storing stimulus features in the neuronal activity. However, the mechanisms protecting WM from task-irrelevant influences are unknown. Recent studies involving WM tasks have suggested that neural activity before and after distractors can be decomposed into two orthogonal subspaces, one invariant across distraction, thus protecting WM from interferences. However, whether orthogonalization is a general mechanism f

Serotonin (5-HT) is an essential neuromodulator affecting behavioral, affective, and cognitive functions. Recent studies by tryptophan depletion in humans and devaluation paradigm in mice suggest that 5-HT promotes model-based decision making. However, the influence of 5-HT on such decision making remains poorly understood. Recent development of rodent two-step decision making tasks enables us to examine the effect of 5-HT manipulations in situations where rewards do not simply reinforce previous choices but rather interact with task structure to influence policy. Here we took a two-step decis