Topic: pilocarpine model

Long-term recordings in patients and animal models reveal circadian and multidien (multiple days) rhythmicity in epilepsy. The underlying mechanisms of these cycles are not known. We are interested in predicting the onset of epileptic seizures over the scale of days. To this end, we performed chronic telemetric and single-unit recordings in epileptic rats (pilocarpine model). The primary focus of our investigation lies in the study of large network discharges known as interictal spikes (IS), closely associated with epileptic seizures.As previously shown, in our recordings the number of seizure

Temporal lobe epilepsy (TLE) is one of the most common forms of drug-resistant epilepsy and its precise etiology is still unknown making it imperative to understand the molecular pathways contributing to the disease. It is, therefore, crucial to study the therapeutic targets and signalling pathways involved in the treatment of this disease. Pyk2 has previously been shown to be activated in stress-mediated pathways in the brain. Consequently, we hypothesized that Pyk2 activation might contribute to the pathogenesis of the disease. A pilocarpine model of TLE was used to examine p-Pyk2Tyr402 prot