Topic: post-traumatic stress disorder (PTSD)

Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in the urocortin 1 (UCN1) positive neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) having modulatory impact on stress adaptation. As post-traumatic stress disorder (PTSD) is triggered by disturbed stress adaptation, we hypothesized the regulatory role of EWcp/UCN1/Trpa1 neurons in PTSD.Methods: Male TRPA1 wild-type (WT) and knockout (KO) mice were exposed to two different models of PTSD. In single prolonged stress (SPS) paradigm, time spent immobility was measured during

Our investigation delves into the intricate interplay between adult hippocampal neurogenesis, a pivotal constituent of long-term memory, and its susceptibility to stress. The ongoing hypothesis is that stress, by impeding neurogenesis, contributes to symptoms associated with post-traumatic stress disorder (PTSD). Our work explores the potential of delta-9-tetrahydrocannabinol (THC), the psychoactive constituent of cannabis, in mitigating stress-induced gene expression alterations in astrocytes, thereby fostering neurogenesis. The initial phase involves inducing cellular stress in an astrocyte-

Post-traumatic stress disorder (PTSD) is a debilitating stress-related psychiatric disorder that can develop following trauma exposure in some individuals. Among others, it is characterized by a dysregulated hypothalamic – pituitary – adrenal axis, which is predominantly regulated by the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). The neurobiological processes leading to disease remain largely unknown. In vitro models are promising tools to investigate specific neurobiological underpinnings of the stress response in the brain. Here, we investigated the suitability of

Strong fear memories resistant to modification are a key hallmark of trauma disorders such as post-traumatic stress disorder (PTSD). However, the neural mechanisms behind the encoding of these memories, and how these may differ in terms of strength, remain poorly understood. In this study, C57BL/6 mice were divided into four treatment groups (strong fear memory, weak fear memory, unpaired strong control, unpaired weak control) and underwent an auditory fear memory reconsolidation paradigm over the course of three days. Brains were stained using immunocytochemistry (ICC) for pERK expression in

Context processing is an essential function in the cognitive repertoire of numerous species, including humans and mice, allowing them to learn from their environment and adapt their future behavior. Impairments or alterations in contextual processing are hypothesized to be at the core etiology of psychopathologies such as post-traumatic stress disorder (PTSD). Current treatment options for anxiety- and trauma-related disorders are limited, mainly due to gaps in our knowledge regarding underlying brain circuits. These gaps are exacerbated since most conclusions from basic research were derived

Previous research has shown that several subcortical brain regions, including the hippocampus, the amygdala, and the thalamus, in patients diagnosed with post-traumatic stress disorder (PTSD) show a reduced volume relative to people who are not diagnosed with PTSD. There are also findings of a reduction of the volume of the corpus callosum in male children that have experienced child maltreatment and female children that have experienced sexual abuse. In this study, we aim to expand this finding to a broader population of trauma-survivors who experienced childhood neglect and/or potentially tr