Topic: dexamethasone

Pregnant women at risk of premature labor receive a single treatment with the synthetic glucocorticoid dexamethasone (DEX) between the 24th and 34th week of pregnancy to ensure adequate maturation of the fetal organs. Due to the postponement of the due date, several doses are often administered. Because purinergic signaling plays an important role in the development of the auditory brainstem, particularly the cochlear nucleus, we investigated whether repeated DEX treatments affect components of the ADP-mediated (NTPDase2 and P2Y1R) and adenosinergic (CD73 and A1R) signaling systems. To compare

Our investigation delves into the intricate interplay between adult hippocampal neurogenesis, a pivotal constituent of long-term memory, and its susceptibility to stress. The ongoing hypothesis is that stress, by impeding neurogenesis, contributes to symptoms associated with post-traumatic stress disorder (PTSD). Our work explores the potential of delta-9-tetrahydrocannabinol (THC), the psychoactive constituent of cannabis, in mitigating stress-induced gene expression alterations in astrocytes, thereby fostering neurogenesis. The initial phase involves inducing cellular stress in an astrocyte-

Post-traumatic stress disorder (PTSD) is a debilitating stress-related psychiatric disorder that can develop following trauma exposure in some individuals. Among others, it is characterized by a dysregulated hypothalamic – pituitary – adrenal axis, which is predominantly regulated by the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). The neurobiological processes leading to disease remain largely unknown. In vitro models are promising tools to investigate specific neurobiological underpinnings of the stress response in the brain. Here, we investigated the suitability of

Neuroinflammation represents a physiological response marked by immune cell activation and the release of inflammatory markers within the central nervous system. While it plays a pivotal protective role, when dysregulated it is also implicated in various neurological disorders such as Alzheimer disease. Brain organoids, self-organized three-dimensional (3D) aggregates derived from human induced pluripotent stem cells (iPSC), have emerged as a novel model to study brain development and disease. This study focuses on the development of a cerebral organoid model of neuroinflammation using pro and