Topic: Precision psychiatry

Corey Keller discusses how transcranial magnetic stimulation can probe and influence brain networks. He explains efforts to measure the brain's response to stimulation and to understand why treatment outcomes differ, outlining the opportunities and remaining uncertainties in developing more precise psychiatric interventions.

Leanne Williams explores how brain imaging could help explain biological differences among people with similar mental-health symptoms. She describes research on brain-network patterns in depression and the possibility of using those measurements to support more individualized diagnosis and treatment.

Electroencephalography (EEG) has been thoroughly studied for decades in psychiatry research. Yet its integration into clinical practice as a diagnostic/prognostic tool remains unachieved. We hypothesize that a key reason is the underlying patient's heterogeneity, overlooked in psychiatric EEG research relying on a case-control approach. We combine HD-EEG with normative modeling to quantify this heterogeneity using two well-established and extensively investigated EEG characteristics -spectral power and functional connectivity- across a cohort of 1674 patients with attention-deficit/hyperacti