Topic: pregnancy

Stephen Quake describes how circulating cell-free nucleic acids became a basis for non-invasive diagnostics. Combining genome knowledge with high-throughput sequencing made liquid biopsies useful in pregnancy, transplantation, infection and cancer. The lecture follows the development of blood-based tests that can replace some invasive tissue-sampling procedures.

Talk(1): Fetal and maternal NLRP3 signaling is required for preterm labor and birth. (DOI: 10.1172/jci.insight.158238) Talk(2): Maternal IL-33 critically regulates tissue remodeling and type 2 immune responses in the uterus during early pregnancy in mice (DOI: 10.1073/pnas.2123267119)