Topic: presenilin-1

Methylglyoxal (MGO), a potent dietary glycotoxin, serves as a key precursor to Advanced Glycation End products (AGEs), which have been linked to an increased risk of Alzheimer's disease (AD) exacerbation. Recognising the significance of lifestyle modifications, particularly nutritional interventions, in preventing brain deterioration, this study aimed to reveal the potentially harmful effects associated with a high-MGO diet on both brain and gut health.Our findings demonstrated MGO administration adversely affected working memory, inducing neuroinflammation and oxidative stress by modulating t

During embryonic development, some of the proliferating neural stem cells enter a quiescent state and is retained till adulthood, thus contributing to adult neurogenesis, a process involving different proteins. From a published microarray of Presenilin-1 knock out embryo, one such protein, VCAM1 was found to be significantly downregulated. In addition, Presenilin-1(PS1) is known to be involved in embryonic neurogenesis as well as in cell cycle regulation. Based on these, we hypothesized PS1 to have a role in neural stem cell quiescence.To address this, we modelled quiescence in vitro by additi