Topic: preterm infants

Periventricular leukomalacia (PVL) is a brain injury seen in preterm infants and causes a significant social, cultural, and economic burden by introducing permanent disabilities throughout life. Cognitive and motor impairments observed during the follow-up in cases with PVL limit their ability to participate in society. Colostrum milk, the first milk produced after birth, is a unique biological fluid. It is thought to have functions other than nutrition with its contents like microRNAs, extracellular vesicles, and neurotrophic mediators. Studies show that colostrum can be neuroprotective when

In preterm infants, hypoxic injury to premyelinating oligodendrocytes leads to failure of oligodendroglial maturation causing long-term neuromotor disabilities. As astrocytes influence oligodendrocyte maturation, this study aimed to analyze the transcriptomic changes in astrocytes after hypoxic injury, to identify possible pathways influencing myelination. Human fetal neural stem cell-derived astrocytes, expressing astrocyte-specific glial fibrillary-acidic protein (GFAP) and excitatory amino acid transporters (EAAT1 and EAAT2), were exposed to hypoxia (0.2% oxygen) and normoxia (20% oxygen) f

White matter injury (WMI) is frequently observed in preterm infants, despite advances in neonatal care. Hypoxia is a key contributing factor which, through heightened vulnerability of preterm newborns, leads to oligodendrocyte dysmaturation, ultimately impairing essential myelination processes. To date, no known effective treatment exists. Considering our recent finding, that inhibiting GPR17 enhances oligodendrocyte progenitor cell (OPC) differentiation and myelination following optic nerve crush, we aimed to investigate the impacts of genetic and pharmacological manipulation in a WMI model.C