Topic: Prime Editing

Develop, optimise and transfer RNA manufacturing processes supporting Prime Editing programmes. Hands-on work includes solid-phase synthesis of long guide RNAs, chromatography, tangential-flow filtration and lyophilisation across scales, alongside GLP/GMP material production, analytical interpretation and technical documentation. The position works across research, technical development, external manufacturing and quality. The advertised annual base salary is USD 80,000–90,000, with additional incentive eligibility.

Guide Prime Editing programmes from preclinical research into human studies. The medical director develops trial strategies and protocols, monitors participant safety and clinical data, and works with research colleagues on translational biomarkers. Responsibilities also include investigator engagement, regulatory discussions and scientific presentations. The role is based in Cambridge, Massachusetts, with travel of up to 25%.