Topic: prodromal phase

Multiple sclerosis (MS) is a chronic demyelinating disease estimated to affect 2.8 million people globally. Recent human studies indicate that MS is not merely a consequence of demyelination, but it also involves an intricate neuronal component, which remains poorly understood. Here, we employed the experimental autoimmune encephalomyelitis (EAE) mouse model of MS to study the neuronal response during autoimmune neuroinflammation, with a particular focus on the prodromal phase, which precedes axonal demyelination. We implemented Targeted Recombination in Active Populations (TRAP) and a compreh

The degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) is a hallmark of Parkinson’s disease (PD). Nevertheless, little is known about the molecular signals that are altered in the prodromal phase in the adult striatum. To address this, we have used spatial transcriptomics and single-nucleus RNA sequencing to characterize the molecular events in mouse models of prodromal PD. We have used two different PD models: a) a progressive dopamine degeneration model of mitochondrial dysfunction (MitoPark mice), and b) a mild toxin model based on a low-dose unilateral 6-hydr