Topic: Progressive supranuclear palsy

Neurodegenerative disorders have a substantial immune component, implicating both peripheral and central immune systems. Despite neuroinflammation being linked to greater dementia risk, the interaction of central and peripheral inflammatory processes to influence disease courses remain ill-understood. A key site-of-interest for this interaction is the choroid plexus. Beyond secreting cerebrospinal fluid (CSF), it has been proposed as a gateway for peripheral immune cell entry into the central nervous system (CNS). As such, increases in choroid volume measurable with structural magnetic resonan

Neurodegenerative diseases like Alzheimer’s disease and Progressive Supranuclear Palsy (PSP) exhibit synaptic loss. In these conditions, synaptic loss precedes neuronal degeneration, and the degree of synaptic loss correlates closely with the severity of clinical symptoms. Both Aβ, which accumulates in amyloid plaques in AD, and tau protein which accumulates intracellularly in tauopathies, accumulate within synaptic terminals. In model systems, the accumulation of Aβ and tau in synapses has been linked to synaptic dysfunction, synaptic loss, and the spread of pathology trans-synaptically. Howe