Protein homeostasis

…Relevant topics include senescence, protein homeostasis, metabolism, mitochondrial biology, genome stability, epigenetic regulation, stem cells and the neurobiology of aging. The appointment includes teaching, mentoring, collaborative research and university service. Priority review is 15 November 2026.

Heat shock proteins (HSPs) are evolutionarily conserved chaperones. Previously our group observed that overexpression of HSPB1 improved certain symptoms of Alzheimer’s disease (AD) in mice. The primary role of these chaperons is to maintain the protein homeostasis, however, several evidence suggest that they have additional functions, such as regulating inflammation. Therefore, our aim is to investigate the role of HSPB1 in chronic neuroinflammation and glia activation in a mouse model of AD.AD model (APP/PS1) mouse strain was crossed with an HSPB1 overexpressing line. Expression pattern of HS

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Heat shock protein 60 (Hsp60) functions as a molecular chaperone, playing a vital role in maintaining protein homeostasis by regulating protein folding and preventing protein aggregation. Levels of heat shock proteins increase in response to oxidative stress and mitochondrial damage, both of which are symptoms commonly associated with various forms of epilepsy. Hsp60 levels are increased in the plasma of patients with temporal lobe epilepsy (TLE). It is crucial to understand what conformations and functions Hsp60 obtains within its folding cycle to determine Hsp60’s role in seizure response. F

Dietary protein quantity and quality greatly impact metabolic health via evolutionary-conserved mechanisms that ensure avoidance of amino acid imbalanced food sources, promote hyperphagia when dietary protein density is low, and conversely produce satiety when dietary protein density is high. Growing evidence support the emerging concept of protein homeostasis in mammals, where protein intake is maintained within a tight range independently of energy intake to reach a target protein intake. The behavioural and neuroendocrine mechanisms underlying these adaptations are unclear and form the focu

…A common emerging theme are defects in protein homeostasis