Topic: protein turnover

Establishing, maintaining and dynamically modifying synaptic connections is a key principle of neuronal computations. The underlying molecular resource of these processes is synaptic proteins. Tight control of protein levels across neurons is crucial to ensure synaptic function. Changes in the synaptic proteome have been associated with compromised synaptic function and in severe cases various diseases. Among the major factors in regulating protein levels are thought to be protein synthesis, trafficking and degradation. While there is substantial literature on protein synthesis, both trafficki