Proteins

…to experimental workflows studying how proteins and their interactions shape synaptic physiology and brain-circuit connectivity.

…for biomedical research across proteins, cells, tissues and organisms. Researchers choose computational and biomedical mentors from affiliated Broad, MIT or Harvard faculty. Review begins after 22 December 2026. The initial one-year appointment may renew for two further years; the expected start is July 2027 or by agreement. Visa sponsorship is available.

…often described only for particular proteins. This talk examines a broader mechanism: small molecules modify colloidal interactions in proteins, DNA and synthetic nanoparticles. Measurements of osmotic virial coefficients and potentials of mean force reveal consistent effects across these systems. A model of weakly interacting amino acids binding to patchy colloidal surfaces predicts experimentally measured dissociation constants; proline–lysozyme predictions and measurements agree

…Examples from natural language, proteins and DNA illustrate both practical model designs and uses of fine-grained control in scientific sequence generation.

Proteins and membranes form remarkably complex structures that are key to intracellular compartmentalization, cargo transport, and cell morphology. Despite this wealth of examples in living systems, we still lack design principles for controlling membrane morphology in synthetic systems. With experiments and simulations, we show that even the simple case of spherical or rod-shaped nanoparticles binding to lipid-bilayer membrane vesicles results in a remarkably rich set of morphologies that can be reliably controlled via the particle binding energy. When the binding energy is weak relative to a