Support large-scale molecular profiling of neuronal populations and synapses in the Brain Proteome Organization team. Contribute to experimental workflows studying how proteins and their interactions shape synaptic physiology and brain-circuit connectivity.
In Biology and Biochemistry
Seminar · Biophysics
Adhering, wrapping, and bursting of lipid bilayer membranes: understanding effects of membrane-binding particles and polymers
Anthony Dinsmore · University of Massachusettes Amherst
Wed, Sep 30, 2020 · 08:00 UTC
Proteins and membranes form remarkably complex structures that are key to intracellular compartmentalization, cargo transport, and cell morphology. Despite this wealth of examples in living systems, we still lack design principles for controlling membrane morphology in synthetic systems. With experiments and simulations, we show that even the simple case of spherical or rod-shaped nanoparticles binding to lipid-bilayer membrane vesicles results in a remarkably rich set of morphologies that can be reliably controlled via the particle binding energy. When the binding energy is weak relative to a