Topic: rate model

An increase in beta-band frequency (13-30 Hz) activity has been observed in different nuclei of the basal ganglia (BG) of patients with Parkinson's disease (PD). However, recent studies have shown that beta oscillations are not only specific to pathological conditions. They have been shown to occur during sensorimotor tasks in healthy subjects. In this study, we used both a rate model and a spiking neural network to investigate the mechanisms responsible for the generations of beta oscillations. Results show that using a rate model with realistic time constants, the classical candidate - a rec

The basal ganglia (BG) circuit, together with the motor cortex and the thalamus, plays an essential role in voluntary movement. In Parkinson’s disease (PD) patients, these structures exhibit exaggerated oscillations in the beta frequencies (10-30 Hz), a phenomenon also observed in animal models of parkinsonism, namely rats and non-human primates (NHP). Several potential generation mechanisms explaining this oscillatory activity have been hypothesized in various theoretical models, but a consensus has yet to be reached. Moreover, the extensive literature characterizing these oscillations and th