Topic: reactive glial cells

Alzheimer’s Disease (AD) is the main form of dementia, currently affecting more than 55 million people worldwide. There is a pressing clinical need for a definitive diagnostic test and effective therapy for AD. Light-based label-free techniques are particularly promising as they provide 3D imaging capabilities with chemical specificity and subcellular resolution. Vibrational spectroscopy methods have reached a level of advancement which enables translational medicine and potential for diagnosis and therapy. Our previous work has applied Fourier Transform Infrared (FTIR) imaging, Raman and Bril

Huntington’s disease (HD) is a genetic neurodegenerative disorder that can result in motor, mood and cognitive symptoms. HD pathophysiology has been linked to neuroinflammation, which is the presence of inflammatory mediators and reactive glial cells in the brain parenchyma. Many signalling pathways likely interact to propagate neuroinflammation and contribute to cell loss. Previous literature indicates that in the anterior cingulate cortex, cell loss and neuroinflammation are correlated with HD mood symptoms. This project gives insight into inflammation-related differential gene expression in