Topic: remapping

The vertebrate telencephalon is the site of complex cognitive processes such as spatial cognition. The larval zebrafish telencephalon is a compact circuit of ~10,000 neurons that nevertheless contains homologous structures to the mammalian basal ganglia and limbic system (e.g. hippocampus and amygdala). However, despite long-standing evidence that spatial navigation and learning in adult fish requires an intact telencephalon, cells believed to underlie spatial cognition in mammals (e.g. place and grid cells) have yet to be established in any fish species. Using a tracking microscope to image b

When animals are placed in multi-compartment or complex environments, entorhinal grid cells exhibit fragmentation of their highly regular spatial tuning curves, with a disjoint grid map for each compartment. However, as the animal explores and increases familiarity with the environment’s geometric and topological structure, the grid maps gradually approach a single globally consistent periodic map [1,2]. Here we show that Hippocampal-MESH — a novel neocortical-hippocampal-entorhinal recurrent circuit model that we introduce in parallel submitted abstracts — can, with the addition of slow plast

Remembering the context in which an aversive experience occurred is critical to safely navigating the environment. The hippocampus (HPC) has been implicated in the encoding of spatial information through the presence of place cells (PC) which are tuned to specific locations in space. As a population, PCs form a “cognitive map” of the environment that adapts to contextual changes through remapping. The dorsal and ventral parts of the hippocampus have different functional implications in spatial coding. While the dorsal HPC mainly processes spatial information, the ventral HPC encodes valence an

Spatial navigation impairments are among the earliest clinical manifestations of Alzheimer’s Disease (AD). Pyramidal cells of the hippocampus fire selectively when the animal is in a specific location in the environment, leading to the theory that the hippocampus plays a crucial role in forming a cognitive map of the environment. The phenomenon of “remapping”, where specific cells exhibit selective firing in distinct environments, is thought to support the formation of different memories. By performing in-vivo electrophysiological recordings in freely moving mice while they navigate through di

Abundant work has highlighted the functional role of the hippocampal formation in navigation behaviour across species. Recent studies highlight evidence that the same neural coding mechanisms found to underly the representation of physical spaces also apply to conceptual domains. Specifically, the representation of locations in both physical and conceptual spaces is reflected in distinct neural activity patterns in hippocampus and entorhinal cortex. Electrophysiological work from rodents has shown that single hippocampal place cells represent different locations in different spaces – a functio

In this study, we investigate how contextual memory is shaped by observational fear learning during encoding and recall. We are imaging neurons in layer 2/3 of the retrosplenial cortex in GCaMP6s mice with two-photon Ca2+ imaging using a head-fixed observational fear learning paradigm in virtual reality. The animals are surrounded by three screens and run on a running wheel as they travel through 3 different VR environments. In two of the environments, we play recordings of mouse vocalisations emitted while they were receiving foot shocks, and a neutral sound in the third environment. A single