Topic: respiratory depression

I show new idea how mu-opioids and high prenatal nicotine cause respiratory slowdown linked toslow wave sleep. A high dose of mu-opioids overstimulates the medial habenula whichactivates the interpeduncular nucleus. The IPN causes respiratory depression via its output toPAG, DRN, MRN, or LPO-RMTg.SWS is linked to a natural slowdown of respiration and heart rate. The MHb and rostromedial tegmental nucleus are known for high amount of mu-opioid receptors. Both MHb and RMTg were proposed to be activated in the neural circuit that promotes SWS, rest, immune defense and recovery (Vadovičová, 2015).

The µ-opioid receptor (MOP) plays a pivotal role in mediating both the therapeutic effects and abuse potential of opioid drugs. However, the comprehensive understanding of the large-scale brain effects resulting from MOP activation remains elusive. In this study, we introduce a multimodal experimental pipeline combining awake functional ultrasound (fUS) imaging through the intact skull with behavioural and molecular measurements to assess the dynamics and physiological relevance of opioid-induced changes in brain activation and functional connectivity (FC) patterns. Application of the major op