Topic: resting-state functional MRI

The balance between neural excitation and inhibition (E/I) is crucial for cognitive functions such as memory formation and retrieval. Disruptions in E/I balance are implicated in neurodegenerative diseases like Alzheimer's disease (AD), where neuronal hyperexcitation has been observed. We present a novel multimodal model that integrates resting-state functional MRI and diffusion-weighted imaging to recapitulate functional and structural connectivity dynamics with high fidelity (citations omitted: double-blind review). This model provides a whole-brain, systems-informed measure of excitation-in

In rodents, the glymphatic system is critically involved in the clearance of brain waste products. In humans, the coupling (i.e., correlation) of resting-state functional MRI signals of global grey matter (gGM-fMRI) and the cerebrospinal fluid signal in the fourth ventricle (CSF-fMRI) is thought to reflect macroscopic glymphatic fluid movement, suggesting relevance for brain clearance. However, direct evidence linking gGM-CSF coupling with brain clearance measures is still missing. We hypothesized that in humans, gGM-CSF coupling is associated with two other measures of the glymphatic system,