ePoster · Hemodynamics
Where and why do neutrophils stall in retinal microcirculation: Data from low-grade systemic inflammation model in the mouse
Meftun Doğa Başaran, Melike Sever Bahçekapılı, Canan Çakır Aktaş, Turgay Dalkara, Şefik Evren Erdener · FENS Forum 2024
Excessive capillary flow heterogeneity results in a microcirculatory dysfunction and hinders optimal oxygen delivery into central nervous system (CNS). Irregularities in cellular flow, like dynamic stalls in capillaries is a potential origin of this heterogeneity. Because under systemic inflammatory conditions neutrophils can become activated and stiffen, they may potentially contribute to capillary stalling of higher frequency and duration. In this study, low dose intraperitoneal lipopolysaccharide (LPS) was administered to transgenic mice with fluorescent capillary pericytes, to induce a low