ePoster · Neuroscience
Population Dynamics and Network Behaviour of ON- and OFF-cells in the Rostral Ventral Medulla
Carl Ashworth, Caitlynn De Preter, Melissa Martenson, Zhigang Shi, Mary Heinricher, Flavia Mancini · Bernstein Conference 2024
Chronic pain is a serious clinical and scientific problem, affecting 1 in 5 people worldwide, yet its mechanisms and ways to treat it remain poorly understood. Pain is modulated by endogenous pain modulatory pathways that connect the brain to the spinal cord, up- and down-regulating the transmission of nociceptive information. The most important region when such modulation occurs is the Rostral Ventromedial Medulla (Fields et al., 1983; Chen and Heinricher, 2022). Despite extensive work characterising the responses of RVM cells during pharmacological interventions, little is currently known ab