Topic: Rotarod

The effects of spaceflight are induced by three concomitant factors: poor social interactions in a reduced living space, microgravity, and the radiation bath. To understand how these parameters can influence behaviors, animal studies are being carried out, modelling each of these parameters independently or not of the others. These studies allow to challenge different strategies of countermeasures to prevent spaceflight multisystemic deconditioning. In the NEBULA project, we developed an original suspension system that allows interaction between 2 conspecifics, to tackle the effects of microgr

Most children with developmental coordination disorders have sensorimotor impairments and reduced physical activity, which can lead to cognitive and motor disorders. On the contrary, physical activity is widely known for its beneficial effects on the body, especially during childhood. Indeed, physical activity is essential for the development of the neuromuscular system, allowing the acquisition of coordination and increasingly precise movements during the first years of life. In order to better understand the effects of atypical sensorimotor experiences during childhood, a model of early sens

The global demographic shift towards an aging population raises concerns about the increasing prevalence of social isolation (SI) among older adults, a concern further highlighted by the recent COVID-19 pandemic. SI is associated with an increased risk of depression, anxiety, and cognitive impairment, exacerbating the global health issue of age-related cognitive decline. Research on the effects of SI in older animals is limited. However, in humans, the negative effects of SI become more pronounced with age, with a particularly strong effect on males. Our study examines the impact of SI on cogn

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron death, leading to motor paralysis and cognitive and behavioural disorders. In clinical trials, ALS patients are stratified by disease stage, whereas in preclinical studies, animals are recruited based solely on age, neglecting individual disease progression. Additionally, both ALS onset and progression are influenced by sex, a factor often mirrored in animal models. This mismatch might contribute to the frequent failures of translating preclinical data to clinical success, suggesting the impo