Motor function

…This study aims to characterize the motor function and brain morphological phenotype of CYP2C19 transgenic mice. Experiments were performed in CYP2C19 transgenic mice with wild-type littermates as controls, in both sexes. Maximal hind paw elevation while walking was measured from video recordings of the footprint test. Structural T1-weighted MRI scans were

We investigated whether a synergistic effect would emerge in post-stroke treatment by opening the blood-brain barrier (BBB) with focused magnetic stimulation (MagStim) and delivering Atorvastatin-Loaded PEGylated Liposomes (LipoStatin). Two weeks after middle cerebral artery occlusion (MCAO), magnetic nanoparticles (MNP) were injected at a concentration of 15mg/ml, followed by 30 minutes of MagStim. The procedure was conducted over a week with MagStim, and magnetic nanoparticles (MNP) were injected three times at two-day intervals. After MagStim, LipoStatin at 10mg/kg was administered intraven

Most children with developmental coordination disorders have sensorimotor impairments and reduced physical activity, which can lead to cognitive and motor disorders. On the contrary, physical activity is widely known for its beneficial effects on the body, especially during childhood. Indeed, physical activity is essential for the development of the neuromuscular system, allowing the acquisition of coordination and increasingly precise movements during the first years of life. In order to better understand the effects of atypical sensorimotor experiences during childhood, a model of early sens

The global demographic shift towards an aging population raises concerns about the increasing prevalence of social isolation (SI) among older adults, a concern further highlighted by the recent COVID-19 pandemic. SI is associated with an increased risk of depression, anxiety, and cognitive impairment, exacerbating the global health issue of age-related cognitive decline. Research on the effects of SI in older animals is limited. However, in humans, the negative effects of SI become more pronounced with age, with a particularly strong effect on males. Our study examines the impact of SI on cogn

Alzheimer’s disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia. During AD pathogenesis, tau is abnormally phosphorylated and aggregating within neurons. As a result of continuous intraneuronal tau aggregation, neurofibrillary tangles are formed. The aim of our project is to determine, whether inhibiting tau protein aggregation with a novel anti-aggregative compound “RE01” improves survival, behavior and neuropathology in a tau-transgenic mouse model. RE01 is an

…and to explore the correlation between motor disability and the altered delta oscillation in STN following stroke. Methods: 10 Sprague-Dawley rat were included in this study. They were trained in single pellet reaching task before stroke induction and motor performance was determined as baseline. STN was recorded before and 30 mins within after stroke. A photothrombotic ischemic lesion ipsilateral to the STN recording site was induced in M1. 3 days after the stroke, we evaluated motor performance using t

Objectives To determine whether plasma neurofilament light chain (pNfL) can be a reliable and minimally invasive biomarker for monitoring response in children with later-onset spinal muscular atrophy (SMA) undergoing nusinersen treatment.Methods Neurofilament light chain(NfL) levels were measured from plasma(pNfL) and cerebrospinal fluid (cNfL) of 40 children with later-onset SMA undergoing nusinersen treatment. A total of 480 CSF and plasma samples were taken during the first six doses of treatment from April 2021 to February 2023. Correlational analyses was used to determine the relationship

Amyotrophic lateral sclerosis (ALS) involves progressive loss of upper and lower motor neurons, leading to paralysis and death within 5-year post-onset. To test if motor neuron progenitors (MNPs) are prospective for rescuing motor function in ALS patients, we derived MNPs from human bone marrow stromal cells (hBMSCs) and used SOD1G93A mutant mice to model ALS. The hBMSC-MNPs were transplanted to (i) the lateral ventricles of neonates (postnatal day 8) or (ii) the spinal cords of adults (P50-60). In the neonatal model, the hBMSC-MNPs survived in the cerebral cortex and extended axonal fibers in

…Functional neuroimaging studies have consistently identified a network of regions, including Supplementary Motor Area and basal ganglia, that are activated when participants make judgements about the duration of currently unfolding events. In parallel, left parietal cortex and cerebellum are activated when participants predict when future events are likely to occur. These structures are activated by temporal processing even when task goals are purely perceptual. S

…translates into aberrant brain function, which can manifest for example as impaired learning, motor function, or social interaction. Despites years of investigation in animal models and clinical research on neurodevelopmental disorders, there are currently no approved pharmacological treatments for core symptoms of the vast majority of them. Here, I will share some recent work (but also some appr