Topic: motor function

We all have a sense of time. Yet it is a particularly intangible sensation. So how is our “sense” of time represented in the brain? Functional neuroimaging studies have consistently identified a network of regions, including Supplementary Motor Area and basal ganglia, that are activated when participants make judgements about the duration of currently unfolding events. In parallel, left parietal cortex and cerebellum are activated when participants predict when future events are likely to occur. These structures are activated by temporal processing even when task goals are purely perceptual. S

Neurodevelopmental disorders are a group of very heterogeneous diseases in which the development of the central nervous system is defective. In neurodevelopmental disorders defective brain development translates into aberrant brain function, which can manifest for example as impaired learning, motor function, or social interaction. Despites years of investigation in animal models and clinical research on neurodevelopmental disorders, there are currently no approved pharmacological treatments for core symptoms of the vast majority of them. Here, I will share some recent work (but also some appr

CYP2C19 is mainly, a liver enzyme that metabolizes psychotropic compounds, however, it is also expressed in the fetal brain. Transgenic knock-in mice carrying the human CYP2C19 gene show the same expression pattern of this enzyme as humans. This study aims to characterize the motor function and brain morphological phenotype of CYP2C19 transgenic mice. Experiments were performed in CYP2C19 transgenic mice with wild-type littermates as controls, in both sexes. Maximal hind paw elevation while walking was measured from video recordings of the footprint test. Structural T1-weighted MRI scans were

Objectives: We aim to investigate the impact of acute stroke on delta oscillation in STN and to explore the correlation between motor disability and the altered delta oscillation in STN following stroke. Methods: 10 Sprague-Dawley rat were included in this study. They were trained in single pellet reaching task before stroke induction and motor performance was determined as baseline. STN was recorded before and 30 mins within after stroke. A photothrombotic ischemic lesion ipsilateral to the STN recording site was induced in M1. 3 days after the stroke, we evaluated motor performance using t