Topic: rsfMRI

Autism Spectrum Disorder (ASD) describes a diverse group of neurodevelopmental disorders encompassing a wide range of clinical impairments. The two core symptoms that define ASD are social communication impairments and restricted and repetitive behaviors, and there is a wide range of cognitive and language abilities. How distinct neurobiological substrates give rise to differing clinical symptoms in subsets of ASD patients is unknown. Using a large, publicly available neuroimaging dataset comprising resting state functional magnetic resonance imaging (rsfMRI) scans from N=299 subjects with ASD

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by distinct pathologies, including extracellular amyloid beta (AB) deposition and intracellular tau burden. Functional connectivity (FC), the correlation of neuronal signalling between different brain regions, is often impaired in neurological diseases, including AD. Our research focused on investigating the impact of AB pathology on FC using a murine model. We utilized the APP-NLGF (APPKI3) mice as our AD model and compared them with APP-NL (APPKI1) mice as controls. We examined FC changes at two time points: 3