Topic: SCENIC

Erythropoietin (EPO), a potent growth factor, named after its role in erythropoiesis, has been shown to not only be produced in the brain, but also to have significant effects in improving cognitive performance. The mechanisms by which EPO acts are yet to be fully explored, including the transcriptome changes elicited by it in the oligodendrocyte lineage. Here we explore these changes after a 3-week EPO/Placebo treatment using single-nuclei RNA sequencing. A total of 12.043 nuclei were classified into 5 cell types (oligodendrocyte precursor cell – OPC, committed oligodendrocyte precursor – COP

Basal ganglia is proposed to mediate symptoms underlying bipolar disorder (BD). To understand the cell type-specific gene expression and network changes of BD basal ganglia, we performed single-nucleus RNA sequencing of 30,752 nuclei from caudate, putamen, globus pallidus, and substantia nigra of control human postmortem brain and 24,672 nuclei from BD brain. Differential expression analysis revealed major difference lying in caudate, with BD medium spiny neurons (MSNs) expressing significantly higher PDE5A, a cGMP-specific phosphodiesterase. Gene co-expression analysis (WGCNA) showed a strong