Topic: seizure severity

Lilii Bulbus (Lilium lancifolium Thunberg) has a proneurogenic effect on the hippocampus. However, its effects on epilepsy and associated pathological features remain unknown. In this study, we investigated the antiseizure effects of a water extract of Lilii Bulbus (WELB) in mouse model of pentylenetetrazol (PTZ)-induced seizure. Mice were injected with PTZ once every 48 h until full kindling was achieved. WELB (100 and 500 mg/kg) was orally administered once daily before PTZ administration and during the kindling process. We found that WELB treatment protected against PTZ-induced low seizure

Seizures produce autonomic symptoms, mainly sympathetic but also parasympathetic in origin. As the vagus nerve (VN) is the main parasympathetic output, the aims of the project is to characterize VN activity during seizures for potential future development closed-loop VNS.Spontaneous seizures were pharmacologically induced in two male Wistar rats (380±14g) by IP kainic acid systemic administration. Surgeries were performed three months after status induction. Three epidural electrodes were implanted for EEG recording. A tripolar Micro-cuff electrode was placed around the left cervical VN to rec